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ea0070yi12 | Young Investigators | ECE2020

Identification of transcriptome profiles in paraffin samples using 3’ RNA-sequencing for the prognostic assessment of adrenocortical carcinoma

Jouinot Anne , Sibony Mathilde , Jeanpierre Lindsay , Septier Amandine , De Murat Daniel , Armignacco Roberta , Perlemoine Karine , Izac Brigitte , Letourneur Franck , Ragazzon Bruno , Leroy Karen , Gaujoux Sebastien , Dousset Bertrand , Groussin Lionel , Libe Rossella , Bertherat Jerome , Assié Guillaume

Background: Adrenocortical cancer (ACC) is an aggressive tumor with heterogeneous prognosis. Previous genomic studies have demonstrated the importance of molecular classification for the prognostic assessment. Among molecular markers, transcriptome profiles “C1A” (steroid and proliferative signature) and “C1B” (immune signature) show the strongest association with outcome. However these markers are determined so far only from frozen tissue samples, sinc...

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Endocrine Abstracts

Identification of transcriptome profiles in paraffin samples using 3’ RNA-sequencing for the prognostic assessment of adrenocortical carcinoma

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